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1453-82-3 Usage


Isonicotinamide, also known as pyridine-4-carboxamide, is a white crystalline powder that is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. It is a pyridinecarboxamide derivative of isonicotinic acid, known for its strong induction of apoptosis in human acute myelomonocytic leukemia cells, such as HL-60.


Used in Pharmaceutical Industry:
Isonicotinamide is used as a heterocyclic building block for the synthesis of various compounds with potential pharmaceutical applications. It is utilized in the creation of 4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives, which are considered as potential anti-tubercular agents. Additionally, it is used in the synthesis of organotin(IV) complexes via the formation of phosphoramidate ligands for various biological activity studies.
Used in Chemical Industry:
Isonicotinamide serves as a key component in the development of bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide, which are potent reactivators for sarin. This application highlights its importance in the chemical industry for creating compounds with specific reactivity and functionality.
Used in Co-crystal Preparation:
Isonicotinamide is also used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals. This application takes advantage of its chemical properties to enhance the properties of the final co-crystal product, potentially improving the performance and effectiveness of the APIs in various pharmaceutical applications.


synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%.

Purification Methods

Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.]

Check Digit Verification of cas no

The CAS Registry Mumber 1453-82-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,5 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1453-82:
73 % 10 = 3
So 1453-82-3 is a valid CAS Registry Number.

1453-82-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A18190)  Isonicotinamide, 99%   

  • 1453-82-3

  • 50g

  • 306.0CNY

  • Detail
  • Alfa Aesar

  • (A18190)  Isonicotinamide, 99%   

  • 1453-82-3

  • 100g

  • 509.0CNY

  • Detail
  • Alfa Aesar

  • (A18190)  Isonicotinamide, 99%   

  • 1453-82-3

  • 250g

  • 1221.0CNY

  • Detail
  • Alfa Aesar

  • (A18190)  Isonicotinamide, 99%   

  • 1453-82-3

  • 500g

  • 2150.0CNY

  • Detail
  • Vetec

  • (V900610)  Isonicotinamide  Vetec reagent grade, 98%

  • 1453-82-3

  • V900610-25G

  • 121.68CNY

  • Detail
  • Vetec

  • (V900610)  Isonicotinamide  Vetec reagent grade, 98%

  • 1453-82-3

  • V900610-100G

  • 286.65CNY

  • Detail
  • Aldrich

  • (I17451)  Isonicotinamide  ReagentPlus®, 99%

  • 1453-82-3

  • I17451-25G

  • 243.36CNY

  • Detail
  • Aldrich

  • (I17451)  Isonicotinamide  ReagentPlus®, 99%

  • 1453-82-3

  • I17451-100G

  • 717.21CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name isonicotinamide

1.2 Other means of identification

Product number -
Other names Pyridine-4-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1453-82-3 SDS

1453-82-3Relevant articles and documents



, p. 306 (1966)


Selective NaOH-catalysed hydration of aromatic nitriles to amides

Schmid, Thibault E.,Gómez-Herrera, Alberto,Songis, Olivier,Sneddon, Deborah,Révolte, Antoine,Nahra, Fady,Cazin, Catherine S. J.

, p. 2865 - 2868 (2015)

The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

Mechanistic studies of the oxidation of isoniazid by the catalase peroxidase from Mycobacterium tuberculosis

Johnsson, Kai,Schultz, Peter G.

, p. 7425 - 7426 (1994)


Synthesis of amidines and benzoxazoles from activated nitriles with Ni(0) catalysts

Gardu?o, Jorge A.,Garc?a, Juventino J.

, p. 3470 - 3477 (2015)

Amidines and 2-substituted benzoxazoles were synthesized from N-heterocyclic nitriles under mild conditions (50 °C, 48 h, two steps) in an atom-economical process that involves addition of methanol, the solvent, to a nitrile moiety to yield a methyl imidate and the subsequent extrusion of solvent in the presence of amines to afford the title compounds. Methyl imidate formation was achieved by developing a new catalytic pathway using [(dippe)Ni(H)]2 (dippe = 1,2-bis(diisopropylphosphino)ethane), [Ni(cod)2]/dppe, or [Ni(cod)2]/P(OPh)3 (cod = 1,5-cyclooctadiene, dppe = 1,2-bis(diphenylphosphino)ethane, P(OPh)3 = triphenyl phosphite) as the catalyst precursor. Regarding the ligands, for a given substrate, namely 4-cyanopyridine, the best performance for the Ni(0)-catalyzed system was found for the σ-donor bidentate dippe, whereas the monodentate π acceptor P(OPh)3 was less efficient. In relation to the substrates, for a given Ni-dippe system, steric hindrance and, more importantly, substrate electron-withdrawing character control imidate formation and thus the yield of amidines and benzoxazoles.

Mechanochemical Synthesis of Primary Amides

Gómez-Carpintero, Jorge,Sánchez, J. Domingo,González, J. Francisco,Menéndez, J. Carlos

, p. 14232 - 14237 (2021/10/20)

Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N-BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug.

Cu2O-Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion

Liu, Wenbo,Tang, Peichen,Zheng, Yi,Ren, Yun-Lai,Tian, Xinzhe,An, Wankai,Zheng, Xianfu,Guo, Yinggang,Shen, Zhenpeng

, p. 3509 - 3513 (2021/10/04)

Nitrogen transfer from cyanide anion to an aldehyde is emerging as a promising method for the synthesis of aromatic nitriles. However, this method still suffers from a disadvantage that a use of stoichiometric Cu(II) or Cu(I) salts is required to enable the reaction. As we report herein, we overcame this drawback and developed a catalytic method for nitrogen transfer from cyanide anion to an alcohol via the complete cleavage of the C≡N triple bond using phen/Cu2O as the catalyst. The present condition allowed a series of benzyl alcohols to be smoothly converted into aromatic nitriles in moderate to high yields. In addition, the present method could be extended to the conversion of cinnamic alcohol to 3-phenylacrylonitrile.

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