1266332-91-5

Basic information

• Product Name: 2,3-bis(3,4-dimethoxyphenyl)acrylic acid
• CAS NO: 1266332-91-5
• Molecular Weight: 344.364
• Mol File: 1266332-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-bis(3,4-dimethoxyphenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(3,4-dimethoxyphenyl)acrylic acid(1266332-91-5)
• EPA Substance Registry System: 2,3-bis(3,4-dimethoxyphenyl)acrylic acid(1266332-91-5)

Safety Data

• Hazardous Substances Data: 1266332-91-5(Hazardous Substances Data)

Upstream product

• 4670-10-4 (3,5-dimethoxyphenyl)acetic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Relevant articles and documents

Efficient synthesis of natural polyphenolic stilbenes: Resveratrol, piceatannol and oxyresveratrol

The practical synthesis of important natural polyphenolic stilbenes, including resveratrol, piceatannol and oxyresveratrol, through Perkin methodology is described. Starting from 3,5-dihydoxyacetophenone (1), the common intermediate 3,5-dimethoxyphenylacetic acid (3) can be obtained via methylation and Willgerodt-Kindler reaction. Perkin condensations between (3) and substituted phenylaldehydes 4 furnished E-2,3-diarylacrylic acids 5, followed by decarboxylation in Cu/quinoline giving stilbene intermediates 6 which bear the Z-configuration. Finally, through a simultaneous demethylation/isomerization process in AlI3/CH3CN system, the target compounds 7a-c can be obtained respectively in good to high overall yields. The synthetic method proved to be more concise, trans-specific, mild, economical and commonly applicable.