1266339-07-4Relevant academic research and scientific papers
Enantioselective organocatalytic α-fluorination of cyclic ketones
Kwiatkowski, Piotr,Beeson, Teresa D.,Conrad, Jay C.,MacMillan, David W. C.
supporting information; experimental part, p. 1738 - 1741 (2011/04/17)
The first highly enantioselective α-fluorination of ketones using organocatalysis has been accomplished. The long-standing problem of enantioselective ketone α-fluorination via enamine activation has been overcome via high-throughput evaluation of a new library of amine catalysts. The optimal system, a primary amine functionalized Cinchona alkaloid, allows the direct and asymmetric α-fluorination of a variety of carbo- and heterocyclic substrates. Furthermore, this protocol also provides diastereo-, regio-, and chemoselective catalyst control in fluorinations involving complex carbonyl systems.
