1266348-29-1Relevant academic research and scientific papers
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1
Marcin, Lawrence R.,Higgins, Mendi A.,Zusi, F. Christopher,Zhang, Yunhui,Dee, Michael F.,Parker, Michael F.,Muckelbauer, Jodi K.,Camac, Daniel M.,Morin, Paul E.,Ramamurthy, Vidhyashankar,Tebben, Andrew J.,Lentz, Kimberley A.,Grace, James E.,Marcinkeviciene, Jovita A.,Kopcho, Lisa M.,Burton, Catherine R.,Barten, Donna M.,Toyn, Jeremy H.,Meredith, Jere E.,Albright, Charles F.,Bronson, Joanne J.,MacOr, John E.,Thompson, Lorin A.
, p. 537 - 541 (2011)
Heterocyclic replacement of the isophthalamide phenyl ring in hydroxyethylamine (HEA) BACE-1 inhibitors was explored. A variety of indole-1,3-dicarboxamide HEAs exhibited potent BACE-1 enzyme inhibition, but displayed poor cellular activity. Improvements
