126641-91-6

Upstream product

• 62506-88-1 (E)-N-(phenylmethylene)benzhydrylamine 
• 163083-83-8 N-(3-cyanopropyl)-N-(2-naphthylmethyl)-3-amino-1-propanol 
• 209183-09-5 t-butyl (S)-3-(benzhydrylamino)-3-phenylpropionate 
• 126568-45-4 4-[Benzyl-(3-hydroxy-propyl)-amino]-butyronitrile 
• 126568-44-3 (S)-3-(N-tert-butoxycarbonylamino)-3-phenylpropanenitrile 
• 422565-32-0 (S)-5,9-bis[(4-methylphenyl)sulfonyl]-4-phenyl-1,5,9-triazacyclotridecan-2-one 
• 209183-01-7 methyl 12-amino-3-phenyl-4,8-diazadodecanoate 
• 591-51-5 phenyllithium 
• 126568-41-0 Benzyl-((1R,2S,3S)-4-benzyloxy-2,3-bis-methoxymethoxy-1-phenyl-butyl)-amine 
• 103365-47-5 (S)-3-(tert-butoxycarbonylamino)-3-phenylpropanoic acid 
• 67341-01-9 (R)-N-(tert-butoxycarbonyl)phenylglycinol 
• 126568-49-8 Benzoic acid 3-{benzyloxycarbonyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester 
• 126568-48-7 Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester 
• 126568-50-1 [4-((S)-3-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-(3-oxo-propyl)-carbamic acid benzyl ester 

Downstream Products

• 65094-32-8 (S)-4-phenyl-9-(3-phenylprop-2-enoyl)-1,5,9-triazacyclotridecan-2-one 
• 52249-08-8 tetrahydroperiphylline 

Relevant academic research and scientific papers

A novel synthesis of the macrocyclic spermidine alkaloid (+)-(S)-dihydroperiphylline

A novel, short, and highly stereoselective synthesis of the macrocyclic spermidine alkaloid (+)-(S)-dihydroperiphylline (15) is described. The key synthetic steps were the stereoselective addition of the chiral amine 1 to the cinnamate 2 and cyclization o

Metal-Templated Macrolactamization of Triamino and Tetramino Esters. Facile Synthesis of Macrocyclic Spermidine and Spermine Alkaloids, (S)-(+)-Dihydroperiphylline, (±)-Buchnerine, (±)-Verbacine, (±)-Verbaskine, and (±)-Verbascenine

The total synthesis of spermidine and spermine alkaloids. (S)-(+)-dihydroperiphylline (1), (±)-buchnerine (2), (±)-verbacine (3), (±)-verbaskine (4), and (±)-verbascenine (5), is described. The construction of macrocyclic lactams has been efficiently accomplished by the metal-templated cyclization of triamino esters and tetraamino esters. It was also found that the antimony(III) ethoxide is useful as an intermolecular amidation catalyst.

ENANTIOSELECTIVE TOTAL SYNTHESIS OF (+)-(S)-DIHYDROPERIPHYLLINE

The first enantioselective total synthesis of (+)-(S)-dihydroperiphylline was achieved from (S)-β-phenyl-β-alanine, prepared by chelation controlled phenylation of the Schiff base, by a new route involving 13-membered lactam formation via iminium cyclization.