126645-95-2Relevant academic research and scientific papers
Synthesis of (-)-8-deoxy-7-hydroxy-swainsonine and (±)-6,8-dideoxy-castanospermine
Maggini, Michele,Prato, Maurizio,Ranelli, Massimo,Scorrano, Gianfranco
, p. 6537 - 6540 (1992)
A total synthesis of (1S,2R,7S,8aR)-1,2,7-trihydroxyindolizidine 3 has been achieved in few steps from lactam 4. The dihydroxyderivative 14 has also been prepared with the same general synthetic approach adapting a Michael addition and a thioamide-diazoketone cyclocondensation as key steps.
HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS
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Page/Page column 107-108, (2015/11/09)
The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical composi
