15166-68-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxy-2-pyrrolidinone is used as a potent inhibitor of CDK2/cyclin A for its role in regulating cell cycle progression. It is particularly valuable in the development of therapeutic strategies against cancer, as it can help prevent uncontrolled cell division and tumor growth.
Additionally, 3-Hydroxy-2-pyrrolidinone serves as a pharmaceutical intermediate, which means it is a compound that is used in the synthesis of more complex pharmaceuticals. Its presence in the synthesis process allows for the creation of a wide range of drugs with various therapeutic applications, making it a versatile and essential component in the pharmaceutical industry.
Used in Chemical Industry:
In the chemical industry, 3-Hydroxy-2-pyrrolidinone can be utilized as a building block for the synthesis of various organic compounds, including other heterocyclic compounds and specialty chemicals. Its unique structure and functional groups make it a valuable starting material for the development of new molecules with potential applications in various fields, such as materials science, agrochemicals, and more.

InChI:InChI=1/C4H7NO2/c6-3-1-2-5-4(3)7/h3,6H,1-2H2,(H,5,7)

Upstream product

• 19444-84-9 3-hydroxyoxolan-2-one 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 
• 42491-95-2 3-acetoxy-2-pyrrolidinone 
• 13477-53-7 4-amino-2-hydroxybutyric acid 

Downstream Products

• 36069-76-8 2,3-Pyrrolidin-dion 
• 126645-95-2 3-<(tert-butyldimethylsilyl)oxy>-2-pyrrolidinone 
• 97899-23-5 3-(p-toluenesulfonyloxy)-2-pyrrolidinone 

Relevant academic research and scientific papers

Synthesis of γ-Lactams by Mild, o-Benzoquinone-Induced Oxidation of Pyrrolidines Containing Oxidation-Sensitive Functional Groups

The late-stage oxidation of substituted pyrrolidines offers good flexibility for the construction of γ-lactam libraries, and especially in recent years the methods for functionalization of pyrrolidine have been available. We reported a new strategy for oxidation of pyrrolidines to γ-lactams: reaction of pyrrolidine with an o-benzoquinone gives an N,O-acetal by direct oxidation of the α-C-H bond of the pyrrolidine ring, and then the N,O-acetal is further oxidized by the o-benzoquinone to the γ-lactam. Because the first oxidation occurs selectively at the α-C-H of the pyrrolidine ring, oxidation-sensitive functional groups (allyl-, vinyl-, hydroxyl-, and amino groups) on pyrrolidine ring are unaffected. The synthetic utility of this novel method was demonstrated by the facile syntheses of (S)-vigabatrin and two analogues.

Absorption medium and method for removing sour gases from fluid streams, in particular from flue gases

Absorption medium for acid gases comprising an oligoamine (A) of the general formula (I) and a primary or secondary alkanolamine (B) of the general formula (II) in which the weight ratio of oligoamine (A) to the primary or secondary alkanolamine (B) is 0.2 to 4, and also the process for removing acid gases from a gas stream by contacting the gas stream at a pressure of 0.05 to 10 MPa abs with an aqueous solution brought to and maintained at a temperature of 20 to 80° C. of said absorption medium.

Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones

The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.