1266570-08-4Relevant academic research and scientific papers
Pd/C-catalyzed synthesis of N-aryl and N-alkyl isoquinolones via C[sbnd]H/N[sbnd]H activation
Shu, Zhen,Guo, Yuntao,Li, Wei,Wang, Baiquan
, p. 292 - 297 (2017)
Pd/C-catalyzed direct synthesis of N-aryl and N-alkyl isoquinolones was developed via the annulation reactions of benzamides and alkynes in high yields (up to 99%) through the cleavage of C[sbnd]H/N[sbnd]H bonds. The reaction was ligand-free and air was used as oxidant. High regioselectivities were found when unsymmetrical alkynes or meta-benzamides were used as substrates. The heterocyclic carboxamide substrates, such as furan and thiophene derivatives, also afforded the corresponding products in high yields.
Rhodium-catalyzed oxidative coupling/cyclization of benzamides with alkynes via C-H bond cleavage
Mochida, Satoshi,Umeda, Nobuyoshi,Hirano, Koji,Satoh, Tetsuya,Miura, Masahiro
supporting information; experimental part, p. 744 - 746 (2011/01/09)
Oxidative coupling of primary, secondary, and tertiary benzamides with internal alkynes proceeds efficiently under rhodium catalysis to selectively give the corresponding 1:1 and 1:2 coupling products, accompanied by C-H and/or N-H bond cleavages. Some of the products exhibit intense fluorescence in the solid state.
