1266570-80-2Relevant academic research and scientific papers
Diastereoselective Nickel-Catalyzed Carboiodination Generating Six-Membered Nitrogen-Based Heterocycles
Marchese, Austin D.,Kersting, Louise,Lautens, Mark
, p. 7163 - 7168 (2019)
A scalable, diastereoselective nickel-catalyzed carboiodination reaction is reported that avoids metal-based reducing agents. Novel anti-dihydroquinolones and previously unreported tetrahydroquinolines are now readily prepared. The generation of anti-dihydroquinolones is noteworthy, as this selectivity is opposite to that of the Pd variant. Mechanistic insight into the nature of the nickel-catalyzed carboiodination reaction was derived experimentally, suggesting a catalyst-controlled cyclization and stereoretentive reductive elimination.
Palladium-catalyzed carboiodination of alkenes: Carbon-carbon bond formation with retention of reactive functionality
Newman, Stephen G.,Lautens, Mark
supporting information; experimental part, p. 1778 - 1780 (2011/04/18)
We report a palladium-catalyzed carbon-carbon bond-forming reaction between aryl iodides and alkenes. In contrast to traditional cross-coupling reactions, two new bonds are formed, and all of the atoms in the starting materials are incorporated into the p
