1266656-74-9

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 40807-61-2 4-hydroxy-4-phenylpiperidin 
• 172734-33-7 4-hydroxy-4-phenylpiperidine-1-carboxylic acid tert-butyl ester 
• 100-58-3 phenylmagnesium bromide 
• 31633-81-5 1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-phenyl-piperidin-4-ol 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.

DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS

Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.