1266665-23-9Relevant articles and documents
Bromopyridazinedione-mediated protein and peptide bioconjugation
Chudasama, Vijay,Smith, Mark E. B.,Schumacher, Felix F.,Papaioannou, Danai,Waksman, Gabriel,Baker, James R.,Caddick, Stephen
supporting information; experimental part, p. 8781 - 8783 (2011/09/16)
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.