40958-31-4Relevant articles and documents
Programming Bioactive Architectures with Cyclic Peptide Amphiphiles
Kuan, Seah Ling,Wang, Tao,Raabe, Marco,Liu, Weina,Lamla, Markus,Weil, Tanja
, p. 1347 - 1353 (2015)
We present a versatile approach for the synthesis of cyclic peptide amphiphiles of the hormone somatostatin (SST) with tunable lipophilic tails to program bioactive nanoarchitectures. A novel bis-alkylation reagent is synthesized that facilitates the functionalization of SST with a thiol anchor. Different hydrophobic moieties are introduced inspired by a biomimetic palmitoylation approach which opens access to cyclic peptide amphiphiles that display rich self-organization and cell membrane interactions. Made to order: Cyclic peptide amphiphiles prepared by a bioinspired approach are employed to program various bioactive nanoarchitectures that display rich self-organization and cell membrane interactions.
Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy
Zuo, Chao,Yan, Bing-Jia,Zhu, Han-Ying,Shi, Wei-Wei,Xi, Tong-Kuai,Shi, Jing,Fang, Ge-Min
supporting information, p. 5698 - 5702 (2019/06/18)
A new robust strategy was reported for the epimerization-free synthesis of C-terminal Cys-containing peptide acids through mercaptoethanol-mediated hydrolysis of peptide thioesters prepared in situ from peptide hydrazides. This simple-to-operate and highly efficient method avoids the use of derivatization reagents for resin modification, thus providing a practical avenue for the preparation of C-terminal Cys-containing peptide acids.
Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release
Wang, Tao,Ng, David Y. W.,Wu, Yuzhou,Thomas, Jessica,Tamtran, Thuy,Weil, Tanja
supporting information, p. 1116 - 1118 (2014/01/17)
The reaction of bis-sulfone conjugation reagents with disulfide bonds allows the site-specific modification of various peptides and proteins. Herein, we present the intracellular disintegration of bis-sulfide containing somatostatin bioconjugates under co