1266682-56-7Relevant academic research and scientific papers
One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D
Frolova, Liliya V.,Evdokimov, Nikolai M.,Hayden, Kathryn,Malik, Indranil,Rogelj, Snezna,Kornienko, Alexander,Magedov, Igor V.
, p. 1118 - 1121 (2011)
Privileged medicinal scaffolds based on the structures of tetra-and pentasubstituted 2-aminopyrroles were prepared via one-pot multicomponent reactions of structurally diverse aldehydes and N-(aryl-, hetaryl-, alkylsulfonamido)acetophenones with activated methylene compounds. This methodology was used in a four-step synthesis of alkaloids rigidins A, B, C, and D in overall yields of 61%, 58%, 60%, and 53%, respectively. Of these, rigidins B, C, and D were synthesized for the first time.(Figure Presented)
