126709-55-5Relevant academic research and scientific papers
Functionalized phosphanyl-phosphonic acids as unusual complexing units as analogues of fosmidomycin
Montel, Sonia,Midrier, Camille,Volle, Jean-Noel,Braun, Ralf,Haaf, Klaus,Willms, Lothar,Pirat, Jean-Luc,Virieux, David
, p. 3237 - 3248 (2012/07/30)
Fosmidomycin (1a) and FR-90098 are potent inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate (MEP) pathway responsible for the biosynthesis of isoprenoids. This paper describes the synthesis of four types of targets bearing a phosphanyl-phosphonic acid motif as the common core for the inhibition of DXR. In these structures, the hydroxamic acid was replaced by various chelators based on a phosphinic acid linked to different functional groups capable of forming five- or six-membered chelating rings. Copyright
Regio- and Stereoselective Synthesis of Symmetrical and Unsymmetrical 1,3-Diphosphoryl(Phosphonyl, Phosphinyl) Substituted (E)-Propenes
Lu, Xiyan,Tao, Xiaochun,Zhu, Jingyang,Sun, Xiaowei,Xu, Jingyan
, p. 848 - 850 (2007/10/02)
Symmetrical and unsymmetrical 1,3-diphosphoryl substituted (E)-propenes were synthesized by the reaction of 1-acetoxyallyl substituted phosphorus compounds (phosphonates, phosphinates, and phosphine oxides) with O,O-dialkyl phosphonates (O-alkyl phosphinates, or dialkyl phosphine oxides) and bis(trimethylsilyl)acetamide (BSA) in the presence of nickel(II) chloride as catalyst, or with trivalent phosphorus acid esters (phosphites, phosphonites, and phosphinites) using only nickel(II) chloride as the catalyst.
