172487-18-2

Upstream product

• 1638-86-4 diethyl phenylphosphonite 
• 64-17-5 ethanol 
• 644-97-3 Dichlorophenylphosphine 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 1779-48-2 phenylphosphinic acid 
• 2651-85-6 diethyl ethylphosphonite 
• 23588-02-5 ethyl phenylphosphonochloridothioite 
• 40618-45-9 O,S-diethylphenylthiophosphonite 
• 81741-70-0 8-Phenyl-8λ⁵-[1,3,2]oxazaphospholo[2,3-b][1,3,2]oxazaphosphole-2,6-dione 
• 57557-81-0 O-ethyl S-n-propyl phenylphosphonothioate 
• 71-43-2 benzene 
• 7732-18-5 water 
• 78-10-4 tetraethoxy orthosilicate 
• 78-62-6 diethoxy dimethylsilane 

Downstream Products

• 109868-85-1 phenyl-(2-[2]pyridyl-ethyl)-phosphinic acid ethyl ester 
• 7016-64-0 ethyl acetyl(phenyl)phosphinate 
• 115049-34-8 (1-acetoxy-vinyl)-phenyl-phosphinic acid ethyl ester 
• 113511-10-7 (2-acetoxy-ethyl)-phenyl-phosphinic acid ethyl ester 
• 64142-66-1 ethyl (1-phenylamino-phenylmethyl)-phenylphosphinate 
• 20543-67-3 ethyl 2-cyanoethyl(phenyl)-phosphinate 
• 18733-18-1 β-(ethoxy-phenyl-phosphinoyl)-isobutyric acid methyl ester 
• 57483-31-5 ethyl (1?hydroxy?1?methylethyl)phenylphosphinate 
• 875228-41-4 (α-amino-isopropyl)-phenyl-phosphinic acid 
• 23471-89-8 2-(Ethoxy-phenyl-phosphinoyl)-2-hydroxy-propionic acid ethyl ester 
• 23471-95-6 1-(Aethoxycarbonyl)-aethyl-aethylphenylphosphonat 
• 23471-97-8 (Ethoxy-phenyl-phosphinoyloxy)-phenyl-acetic acid ethyl ester 
• 109815-11-4 ethyl heptyl(phenyl)phosphinate 
• 58194-90-4 [1-(N'-Cyclohexylidene-hydrazino)-cyclohexyl]-phenyl-phosphinic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of alkyl α-aminomethyl-phenylphosphinates and N,N-bis(alkoxyphenylphosphinylmethyl)amines by the microwave-assisted Kabachnik–Fields reaction

As a novel extension, the Kabachnik–Fields reaction was applied to the synthesis of alkyl α-aminomethyl-phenylphosphinates, and the double phospha-Mannich reaction was utilized in the preparation of bis(alkoxyphenylphosphinylmethyl)amines. A total of 27 new aminophosphinate derivatives were synthesized by the microwave-assisted solvent-free condensation of alkyl phenyl-H-phosphinates, paraformaldehyde, and primary or secondary amines. The starting P-species were also prepared under microwave conditions. The formation of the N-methylated aminomethyl-phenylphosphinate by-products was also investigated.

Synthesis of the mixed alkyl esters of phenylphosphonic acid by two variations of the Atherton-Todd protocol

Phenylphosphonates with mixed alkyl groups were synthesized from ethyl phenyl-H-phosphinate by twomodified Atherton-Todd methods. Using aqueous sodium hydroxide under phase transfer catalytic conditions, the alkyl ethyl phosphonates were obtained in onlym

Novel synthetic method of phosphonamidate peptides and its application in peptide sequencing via multistage mass spectrometry.

Phosphonamidate peptides were prepared in good yields by reaction of ethoxy(phenyl)phosphinate with free peptides in a mixed solution of H2O, C2H5OH, Et3N and CCl4 at room temp.; their in situ electrospray ionization mass spectra exhibited high sensitivit

Peptide sequencing through N-terminal phosphonylation and electrospray ionization mass spectrometry

Peptides were phosphonylated at their N-termini by reacting with ethoxyphenylphosphinate in the presence of triethylamine and tetrachloromethane under mild conditions. The phosphonylated peptides were analyzed by tandem electrospray ionization mass spectr

Palladium-Catalyzed Domino Cyclization/Phosphorylation of gem-Dibromoolefins with P(O)H Compounds: Synthesis of Phosphorylated Heteroaromatics

We presented a palladium-catalyzed domino cyclization/phosphorylation of gem-dibromoolefins, which utilize H-phosphinates and secondary phosphine oxides as the phosphine sources, respectively. A variety of phosphorylated heteroaromatics were obtained in m

A facile and practical preparation ofP-chiral phosphine oxides

A practical and cost-effective synthetic method ofP-chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during s

Stereo- And Regioselective cis-Hydrophosphorylation of 1,3-Enynes Enabled by the Visible-Light Irradiation of NiCl2(PPh3)2

Described herein is a stereo- and regioselective cis-hydrophosphorylation reaction of the internal alkyne of 1,3-enynes that accesses various 1,3-dienes in good isolated yields. The visible-light irradiation of NiCl2(PPh3)2 allows the generation of highly reactive nickel(II)-phosphorus species that subsequently migrate into the internal alkyne of the 1,3-enynes and protonate the resulting vinyl nickel species, leading to various phosphinoyl 1,3-butadienes under mild reaction conditions.

Visible-light-induced ligand to metal charge transfer excitation enabled phosphorylation of aryl halides

We herein described a visible light induced nickel(II)-catalyzed cross-coupling of secondary phosphine oxides with aryl halides. The Ni(I)species and chlorine atom radical Cl˙ were generatedviathe ligand to metal charge transfer (LMCT) process of the NiCl2(PPh3)2, which allows nickel(IV)-phosphorus speciesin situformation, giving various tertiary phosphine oxides under photocatalyst-free conditions.

B(C6F5)3-catalyzed O-H insertion reactions of diazoalkanes with phosphinic acids

A highly efficient base-, metal-, and oxidant-free catalytic O-H insertion reaction of diazoalkanes and phosphinic acids in the presence of B(C6F5)3has been developed. This powerful methodology provides a green approach towards the synthesis of a broad spectrum of α-phosphoryloxy carbonyl compounds with good to excellent yields (up to 99% yield). The protocol features the advantages of operational simplicity, high atom economy, practicality, easy scalability and environmental friendliness.

Asymmetric synthesis of stereogenic phosphorus P(V) centers using chiral nucleophilic catalysis

Organophosphates have been widely used in agrochemistry, as reagents for organic synthesis, and in biochemistry. Phosphate mimics possessing four unique substituents, and thereby a chirality center, are useful in transition metal catalysis and as nucleotide therapeutics. The catalytic, stereocontrolled synthesis of phosphorus‐stereogenic centers is challenging and traditionally depends on a resolution or use of stochiometric auxiliaries. Herein, enantioenriched phosphorus centers have been synthesized using chiral nucleophilic catalysis. Racemic H‐phosphinate species were coupled with nucleophilic alcohols under halogenating conditions. Chiral phosphonate products were synthesized in acceptable yields (33–95%) and modest enantioselectivity (up to 62% ee) was observed after identification of an appropriate chiral catalyst and optimization of the solvent, base, and temperature. Nucleophilic catalysis has a tremendous potential to produce enantioenriched phosphate mimics that could be used as prodrugs or chemical biology probes.