1267159-50-1Relevant academic research and scientific papers
Visible-light initiated copper(i)-catalysed oxidative C-N coupling of anilines with terminal alkynes: One-step synthesis of α-ketoamides
Sagadevan, Arunachalam,Ragupathi, Ayyakkannu,Lin, Chun-Cheng,Hwu, Jih Ru,Hwang, Kuo Chu
supporting information, p. 1113 - 1119 (2015/03/04)
Development of C-N coupling processes is fundamentally important and challenging for the synthesis of biologically active molecules and drugs. Herein, we report a highly atom efficient green process for the synthesis of α-ketoamides via visible-light induced copper(i) chloride catalysed direct oxidative Csp-N coupling reactions using commercially available alkynes and anilines at room temperature without the use of hazardous chemicals and harsh reaction conditions. Forty-seven examples are presented using a broad range of substrates including electron deficient anilines and various terminal alkynes. The current photochemical process is able to achieve epoxide hydrolase inhibitors in one step with high yield (92-95%). This transformation is highly efficient and highly selective for the synthesis of α-ketoamides. This journal is
Chiral Bronsted acid-catalyzed diastereo- and enantioselective synthesis of CF3-substituted aziridines
Chai, Zhuo,Bouillon, Jean-Philippe,Cahard, Dominique
supporting information, p. 9471 - 9473 (2012/10/30)
A multicomponent organocatalyzed highly diastereo- and enantioselective synthesis of CF3-substituted aziridines is described. This reaction of in situ generated CF3CHN2 and aldimines was realized by chiral Bronsted acid catalysis. The utility of the products is illustrated by easy access to β-CF3 isocysteine and aziridine-containing dipeptides.
