16208-14-3

Basic information

• Product Name: 4-METHYLPHENYLGLYOXAL HYDRATE
• Synonyms: 4-METHYLPHENYLGLYOXAL HYDRATE;4-Methylphenylglyoxal hydrate 95%;4-METHYLPHENYLGLYOXAL HYDRATE, 95+%;(4-Methylphenyl)(oxo)acetaldehyde hydrate;2,2-Dihydroxy-4'-methylacetophenone;NSC 402744;2-(4-Methylphenyl)-2-Oxo-Acetaldehyde
• CAS NO: 16208-14-3
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• Mol File: 16208-14-3.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 235.3 °C at 760 mmHg
• Flash Point: 87.3 °C
• Appearance: /
• Density: 1.101 g/cm³
• Vapor Pressure: 0.0503mmHg at 25°C
• Refractive Index: 1.525
• PKA: 10.66±0.41(Predicted)
• CAS DataBase Reference: 4-METHYLPHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLPHENYLGLYOXAL HYDRATE(16208-14-3)
• EPA Substance Registry System: 4-METHYLPHENYLGLYOXAL HYDRATE(16208-14-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 16208-14-3(Hazardous Substances Data)

Usage

General Description

4-Methylphenylglyoxal hydate is a chemical compound with the molecular formula C9H10O3. It is a hydrate form of 4-methylphenylglyoxal, which is an organic compound containing a benzene ring and a two-carbon chain with a carbonyl group. This chemical is commonly used in the synthesis of various pharmaceutical and organic compounds. It is also used as a reagent in organic chemistry reactions, particularly in the formation of heterocyclic compounds. Additionally, 4-methylphenylglyoxal hydate has potential applications in the development of new materials and chemical research.

InChI:InChI=1/C9H8O2/c1-7-2-4-8(5-3-7)9(11)6-10/h2-6H,1H3

Upstream product

• 122-00-9 para-methylacetophenone 
• 1075-47-4 4-methylphenylglyoxal 
• 17628-76-1 p-tolylglyoxalmonoxime 

Downstream Products

• 1421844-92-9 1-(4-fluorophenyl)-6,7-dihydro-6,6-dimethyl-3-(2-phenyl-1H-indol-3-yl)-2-p-tolyl-1H-indol-4(5H)-one 
• 1421844-93-0 6,7-dihydro-6,6-dimethyl-3-(2-phenyl-1H-indol-3-yl)-1,2-dip-tolyl-1H-indol-4(5H)-one 
• 1430094-19-1 C₃₈H₃₀N₆ 
• 1430094-25-9 C₄₂H₃₄N₆ 
• 1430094-29-3 C₄₀H₃₄N₆ 
• 1430094-04-4 C₂₈H₂₆N₆ 
• 1430094-08-8 C₃₈H₃₀N₆ 

Relevant articles and documents

One-pot, three-component synthesis of polyfunctionalized benzo[h]pyrazolo[3,4-b][1,6]naphthyridine and benzo[g]pyrazolo[3,4-b]quinoline derivatives in the presence of silver nanoparticles (AgNPs)

An efficient and straightforward protocol for one-pot, three-component reaction of aryl glyoxal monohydrates 1a-h, 5-amino-1-aryl-3-methylpyrazoles 2a,b and 4-hydroxyquinoline-2(1H)-one (3) or 2-hydroxy-1,4-naphthoquinone (4) using silver nanoparticles (AgNPs) as a high performance nanocatalyst in H2O/EtOH at 60°C afforded the corresponding polyfunctionalized benzo[h]pyrazolo[3,4-b][1,6]naphthyridines 5a-h and benzo[g]pyrazolo[3,4-b]quinolines 6a-i, respectively. Excellent catalytic activity, high yields, employing green media and green nanocatalyst, cost-effective and simple procedure are some notable advantages of using AgNPs as a noble metal nanocatalyst in this synthetic strategy. The structures of fused heterocycles were confirmed by their Fourier transform infrared, proton nuclear magnetic resonance (1H-NMR), and 13C-NMR spectral data and microanalysis.

A simple protocol for the green synthesis of a new series of pyrimido[4,5b][1,6]naphthyridines in the presence of silver nanoparticles (AgNPs)

Eight polyfunctionalized pyrimidonaphthyridine derivatives has been synthesized, in 79-92% yields, via the one-pot, three-component reaction of aryl glyoxal monohydrates, 6-aminouracil and 4-hydroxyquinolin-2(1H)-one in H2O/EtOH in the presence of AgNPs under mild conditions. In this work colloidal AgNPs acts as an efficient, economical, green nanocatalyst, leading to a simple method of preparation.

A Facile and Effective Procedure for Synthesis of Polyfunctionalized Bis (imidazolyl) Pyrrole/Imidazolyl Indole from Pyrrole/Indole with Arylglyoxals and N-aryl amidines

Heterocyclic systems containing bis (imidazolyl) pyrrole or imidazolyl indole moieties were synthesized by heterocyclization of pyrrole or indole with arylglyoxal monohydrates and N-aryl amidines in ethanol catalyzed by FeCl3 at room temperature. The paper reports a facile, efficient, and environmentally friendly protocol for the synthesis of new products. Products were isolated by simple filtration, and their structures were established from their spectroscopic data.