1267490-97-0Relevant academic research and scientific papers
Synthesis of N-Fused Indolines via Copper (II)-Catalyzed Dearomatizing Cyclization of Indoles
Zhang, Jingyu,Xia, Wei,Huda, Saskia,Ward, Jas S.,Rissanen, Kari,Albrecht, Markus
, p. 3121 - 3126 (2021/05/03)
Herein, a copper(II)-catalyzed dearomative cyclization amination of N-(2-aminobenzoyl) indoles is presented. Under mild reaction conditions, the cyclization proceeds to afford tetracyclic indolines by forming a new C?N bond in good yields. The tetracyclic
Synthesis of Polycyclic Indolines by Utilizing a Reduction/Cyclization Cascade Reaction
Zhang, Jingyu,Xia, Wei,Qu, Meilin,Huda, Saskia,Ward, Jas S.,Rissanen, Kari,Albrecht, Markus
, p. 6097 - 6101 (2021/11/09)
Subsequent reduction and dearomatizing cyclization reactions open up an entry into the synthesis of novel N-fused polycyclic indolines. The dearomatizing cyclization as key step of the sequence proceeds well with Cu(OTf)2 or TfOH as catalyst. At elevated temperature reduction of nitro-substituted precursors with iron under acidic conditions affords a broad variety of polycyclic indolines directly in a two-step cascade reaction in good to excellent yields. Using the developed protocol, the alkaloids tryptanthrin and phaitanthrin C have been prepared.
Iron(III) chloride as a mild catalyst for the dearomatizing cyclization of n-acylindoles
Albrecht, Markus,Zhang, Jingyu,Li, Jing,Ward, Jas S.,Truong, Khai-Nghi,Rissanen, Kari
, p. 12160 - 12174 (2020/11/10)
A catalytic approach for the preparation of indolines by dearomatizing cyclization is presented. FeCl3 acts as a catalyst to afford tetracyclic 5a,6-dihydro-12H-indolo[2,1-b][1,3]benzoxazin-12-ones in good yields. The cyclization also proceeds with tosylamides forming C-N bonds in 53% yield.
Iridium catalyzed asymmetric hydrogenation of cyclic imines of benzodiazepinones and benzodiazepines
Gao, Kai,Wu, Bo,Yu, Chang-Bin,Chen, Qing-An,Ye, Zhi-Shi,Zhou, Yong-Gui
, p. 3890 - 3893 (2012/09/22)
Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee. This method provides a direct access to synthesize a range of chiral cyclic amines existing in nume
Silver-and gold-mediated domino transformation: A strategy for synthesizing benzo[ e ]indolo[1,2-a ]pyrrolo/pyrido[2,1-c ][1,4]diazepine-3,9-diones
Zhou, Yu,Li, Jian,Ji, Xun,Zhou, Wei,Zhang, Xu,Qian, Wangke,Jiang, Hualiang,Liu, Hong
, p. 1239 - 1249 (2011/04/26)
We reported a strategy for the synthesis of fused heterocyclic compounds benzo[e]indolo[1,2-a]pyrrolo/pyrido[2,1-c][1,4]diazepine-3,9-diones via an AgSbF6/gold-complex catalyzed one-pot cascade transformation. The strategy is tolerant of a broad range of substrates and affords a series of intriguing fused diazepinedione heterocycles.(Figure Presented)
