126765-22-8

Upstream product

• 126765-20-6 2-(2-(2-hydroxyethoxy)ethoxy)ethyl-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 
• 98-59-9 p-toluenesulfonyl chloride 
• 77544-68-4 8-tosyloxy-3,6-dioxaoctanol 
• 4163-60-4 β-D-galactose peracetate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 3068-32-4 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside 

Relevant academic research and scientific papers

Mimicking biological membranes with programmable glycan ligands self-assembled from amphiphilic Janus glycodendrimers

An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm. By simple injection of their THF solutions into water or buffer, all of the Janus compounds self-assembled into uniform, stable, and soft unilamellar vesicles, denoted glycodendrimersomes. The mixed constellation topology glycodendrimersomes were demonstrated to be most efficient in binding plant, bacterial, and human lectins. This evidence with biomedically relevant receptors offers a promising perspective for the application of such glycodendrimersomes in targeted drug delivery, vaccines, and other areas of nanomedicine.

DIETHYLENE AND TRIETHYLENE GLYCOL SPACERS FOR THE PREPARATION OF NEOGLYCOPROTEINS

Mono- and disaccharide glycosides of some bifunctional aglycons, such as 3-oxa-pentanediol-1,5 (diethylene glycol), 3,6-dioxa-octanediol-2,8 (triethylene glycol), 5-amino-3-oxa-pentan-1-ol, 5-azido-3-oxa-pentan-1-ol, 8-amino-3,6-dioxa-octan-1-ol, 3,6-dioxa-7-ethoxycarbonyl-heptan-1-ol and 3,6-dioxa-non-8-en-1-ol were synthesized and used to prepare artificial glycoconjugates.These spacer molecules were sequentionally built up either from diethylene- or triethylene glycol monoglycosides, or from diethylene glycol prior to the glycosylation steps.