Angewandte Chemie - International Edition p. 10899 - 10903 (2014)
Update date:2022-08-05
Topics:
Zhang, Shaodong
Moussodia, Ralph-Olivier
Sun, Hao-Jan
Leowanawat, Pawaret
Muncan, Adam
Nusbaum, Christopher D.
Chelling, Kathleen M.
Heiney, Paul A.
Klein, Michael L.
André, Sabine
Roy, René
Gabius, Hans-J.
Percec, Virgil
An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm. By simple injection of their THF solutions into water or buffer, all of the Janus compounds self-assembled into uniform, stable, and soft unilamellar vesicles, denoted glycodendrimersomes. The mixed constellation topology glycodendrimersomes were demonstrated to be most efficient in binding plant, bacterial, and human lectins. This evidence with biomedically relevant receptors offers a promising perspective for the application of such glycodendrimersomes in targeted drug delivery, vaccines, and other areas of nanomedicine.
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