1267753-80-9Relevant academic research and scientific papers
Copper-TEMPO-catalyzed synthesis of α-ketoamides: Via tandem sp3C-H aerobic oxidation and amination of phenethyl alcohol derivatives
Liu, Chengkou,Yang, Zhao,Guo, Shiyu,Zeng, Yu,Zhu, Ning,Li, Xin,Fang, Zheng,Guo, Kai
, p. 8570 - 8575 (2016)
An efficient copper-TEMPO-catalyzed one-pot synthesis of α-ketoamides from phenethyl alcohol derivatives was developed firstly. Moreover, molecular oxygen in open air was employed as the oxidant with a broad substrate scope, which makes this methodology more practical. Based on some control experiments, a plausible mechanism was proposed.
Visible-Light-Promoted Oxidative Amidation of Bromoalkynes with Anilines: An Approach to α-Ketoamides
Ni, Ke,Meng, Ling-Guo,Wang, Kuai,Wang, Lei
supporting information, p. 2245 - 2248 (2018/04/30)
A convenient and practical synthetic route to α-ketoamides from bromoalkynes and anilines through phototriggered organic transformations via a C-N cross-coupling and an oxidation of Ca‰?C was developed. The reaction could be furnished without an external photocatalyst at ambient conditions, and a wide range of α-ketoamides were obtained in good yields.
Copper-catalyzed aerobic oxidative cross-dehydrogenative coupling of amine and α-carbonyl aldehyde: A practical and efficient approach to α-ketoamides with wide substrate scope
Zhang, Chun,Zong, Xiaolin,Zhang, Liangren,Jiao, Ning
supporting information; experimental part, p. 3280 - 3283 (2012/07/31)
A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with α-carbonyl aldehyde has been developed. Many types of amines are tolerant in this transformation leading to various α-ketoamides compounds. Wide substrate scope, CDC strategy and using air as oxidant make this transformation highly efficient and practical. Molecular oxygen acts not only as the oxidant, but also as an initiator to trigger this catalytic process. Furthermore, mechanism studies show that carbonyl group of α-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process.
Copper-catalyzed aerobic oxidative coupling of aryl acetaldehydes with anilines leading to α-ketoamides
Zhang, Chun,Xu, Zejun,Zhang, Liangren,Jiao, Ning
supporting information; experimental part, p. 11088 - 11092 (2012/02/02)
Efficient and practical: The title reaction provides an efficient route to α-ketoamides compounds, which are ubiquitous structural units in a number of biologically active compounds. N-substituted anilines are suitable substrates for this transformation.
