1267766-12-0Relevant articles and documents
Microwave-assisted synthesis, biological evaluation and molecular docking studies of new coumarin-based 1,2,3-triazoles
Ashok, D.,Dharavath, Ravinder,Jyothi, K.,Nagaraju, Nalaparaju,Prashanthi, G.,Reddy, M. Ram,Sarasija, M.,Vani, T.,Vijjulatha, M.
, p. 11615 - 11623 (2020)
Coumarin-based 1,4-disubstituted 1,2,3-triazole derivatives were synthesized using a highly efficient, eco-friendly protocol via a copper(i)-catalyzed click reaction between various substituted arylazides and terminal alkynes. The synthetic route was easy
Facile one-pot synthetic access to libraries of diversely substituted 3-aryl (Alkyl)-coumarins using ionic liquid (IL) or conventional base/solvent, and an IL-mediated approach to novel coumarin-bearing diaryl-ethynes
Kalkhambkar, Rajesh G.,Laali, Kenneth K.,Malunavar, Shruti S.,Prabhala, Pavankumar,Savanur, Hemantkumar M.,Sutar, Suraj M.
supporting information, (2020/04/08)
The in-situ formed carbonylimidazole derivatives of Ar(alkyl)-CH2COOH react at r.t. with substituted salicylaldehydes in [BMIM][PF6] or [BMIM][BF4] as solvent, and [PAIM][NTf2] as basic-IL, to produce libraries of 3-aryl(alkyl)coumarins. Whereas these reactions can also be performed with similar efficiency in THF by employing DBU, the IL approach offers easier work-up and recycling of the IL solvent. An IL-mediated approach to the synthesis of novel coumarin-bearing diaryl-ethynes by the Sonogshira reaction is also reported, and the potential for recycling/reuse of the IL solvent is shown.
Microwave assisted synthesis of 4-methyl-3-arylpyrano[2,3-f]chromen-2(8H)-one derivatives, evaluation of antiproliferative, and antimicrobial activities
Dharavath, Ravinder,Sarasija, Madderla,Ram Reddy, Makthal,Nalaparaju, Nagaraju,Katta, Ramakrishna,Ashok, Dongamanti
, p. 3943 - 3950 (2020/08/28)
A series of new 4-methyl-3-arylpyrano[2,3-f]chromen-2(8H)-one derivatives were designed and synthesized through an efficient, an eco-friendly manner under microwave irradiation and conventional heating methods. Structures of final compounds established ba
A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity
Roussaki, Marina,Kontogiorgis, Christos A.,Hadjipavlou-Litina, Dimitra,Hamilakis, Stylianos,Detsi, Anastasia
experimental part, p. 3889 - 3892 (2010/09/03)
A series of coumarin analogues bearing a substituted phenyl ring on position 3 were synthesized via a novel methodology, through an intermolecular condensation reaction of 2-hydroxyacetophenones and 2-hydroxybenzaldehyde, with imidazolyl phenylacetic acid active intermediates. The in vitro antioxidant activity of the synthesized compounds was evaluated using two different antioxidant assays (radical scavenging ability of DPPH stable free radical and inhibition of lipid peroxidation induced by the thermal free radical AAPH). Moreover, the ability of the compounds to inhibit soybean lipoxygenase was determined as an indication of potential anti-inflammatory activity.
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors
Wang, Yue-Ping,Chen, Fen-Er,De Clercq, Erik,Balzarini, Jan,Pannecouque, Christophe
experimental part, p. 1016 - 1023 (2009/09/29)
A series of new 5-alkyl-2-benzylsulfanylpyrimidin-4(3H)-ones (5a-y) bearing different substituted arylmethyl moieties at the C-6 position of the pyrimidine core have been synthesized and evaluated for their in vitro activities against HIV-1 and HIV-2 in MT-4 cell cultures. The majority of the title compounds showed moderate to good activities against HIV-1 with an IC50 range from 6.67 μM to 0.12 μM. Among them, 6-(3,5-dimethylbenzyl) analogue 5q exhibited the most potent anti-HIV-1 activity (IC50 = 0.12 μM, SI > 2642), which was about 40-fold more active than the reference compounds 1-[(2-hydroxyethoxy)methyl]-6-(phenylsulfanyl)thymine (HEPT) and 2′,3′-dideoxyinosine (DDI). The structure-activity relationships (SARs) of these new congeners were further discussed.
