16807-64-0

Basic information

• Product Name: 3(4'-BROMOPHENYL)COUMARIN
• Synonyms: 3(4'-BROMOPHENYL)COUMARIN
• CAS NO: 16807-64-0
• Molecular Formula: C₁₅H₉BrO₂
• Molecular Weight: 301.13
• Mol File: 16807-64-0.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3(4'-BROMOPHENYL)COUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 3(4'-BROMOPHENYL)COUMARIN(16807-64-0)
• EPA Substance Registry System: 3(4'-BROMOPHENYL)COUMARIN(16807-64-0)

Safety Data

• Hazardous Substances Data: 16807-64-0(Hazardous Substances Data)

Usage

General Description

3(4'-Bromophenyl)coumarin is a chemical compound that belongs to the coumarin family, which is known for its diverse range of biological activities. This particular compound contains a coumarin core structure with a 4'-bromophenyl substituent. It is commonly used in pharmaceutical and medicinal research due to its potential therapeutic properties, including anti-inflammatory, anti-cancer, and antiviral effects. Additionally, 3(4'-Bromophenyl)coumarin has been studied for its ability to modulate enzyme activity and as a fluorescent probe for detecting various biomolecules. Its unique chemical structure and biological activities make it a valuable compound for further exploration in the development of new drugs and medical treatments.

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Relevant articles and documents

Dual Role of Oxoaldehydes: Divergent Synthesis of 3-Aryl- and 3-Aroylcoumarins

A facile and efficient synthetic approach to various valuable 3-aryl- and 3-aroylcoumarins by the direct arylation and aroylation of coumarins with glyoxals in a metal-free manner is presented. The aryl glyoxal is for the first time recognized to serve as an aryl surrogate in addition to its role as an aroyl transfer reagent via a simple switch in reaction conditions. The approach accommodates a broad substrate scope and high yields of the two types of cross-coupling reactions starting from identical starting materials.

Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

We have prepared a series of ten 3-arylcoumarin molecules, their respective fac-[Re(CO)3(bpy)L]+ and fac-[Re(CO)3(L?L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) > 150 μM, when coordinated to the fac-[Re(CO)3]+ core, most of the resulting complexes showed remarkable antibacterial potency. Several rhenium complexes exhibit activity in nanomolar concentrations against Gram-positive pathogens such as Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA) and Enterococcus faecium. The molecules do not affect bacterial cell membrane potential, but some of the most potent complexes strongly interact with DNA, indicating it as a possible target for their mode of action. In vivo studies in the zebrafish model showed that the complexes with anti-staphylococcal/MRSA activity were non-toxic to the organism even at much higher doses of the corresponding MICs. In the zebrafish-MRSA infection model, the complexes increased the survival rate of infected fish up to 100% and markedly reduced bacterial burden. Moreover, all rescued fish developed normally following the treatments with the metallic compounds.

Alpha-hydroxyketone compound containing coumarin, and preparation method and application of alpha-hydroxyketone compound

The invention provides an alpha-hydroxyketone compound containing coumarin, and a preparation method and an application of the alpha-hydroxyketone compound. In the alpha-hydroxyketone compound, R0 ismore than one of a halogen atom, R, OR, SR, SOR, SO2R, N