127492-56-2

Upstream product

• 127492-55-1 C₇₆H₁₂₉F₃O₁₃S₃Si₃ 

Downstream Products

• 127492-58-4 C₈₀H₁₄₁NO₁₃S₂Si₃ 
• 126789-44-4 C₈₀H₁₅₅NO₁₁S₂Si₄ 
• 126789-43-3 C₆₉H₁₃₈O₈S₂Si₄ 
• 127517-03-7 C₆₆H₁₃₂O₉Si₄ 
• 127492-57-3 (1E,9Z)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol 
• 127492-57-3 (1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol 

Relevant academic research and scientific papers

A Formal Synthesis of FK-506. Exploration of Some Alternatives to Macrolactamization

The coupling of the previously described subunits 2, 3, and 4 is described.The C28-C27 E-double bond is fashioned from a sulfurane induced dehydration of alcohol 11.The C19-C20 E-double bond was constructed via a modified Julia process culminating in a reductive elimination of a vicinal trifluoroacetoxy sulfone (see 22 -> 23 -> 24 and 25).The synthesis of intermediates anticipating potential macrolactonization are also described.