12679-56-0
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Basic information
- Product Name: cytochrome P-452
- Synonyms: cytochrome P-452
- CAS NO:12679-56-0
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 12679-56-0.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: cytochrome P-452(CAS DataBase Reference)
- NIST Chemistry Reference: cytochrome P-452(12679-56-0)
- EPA Substance Registry System: cytochrome P-452(12679-56-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 12679-56-0(Hazardous Substances Data)
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General Description
Cytochrome P-450 is a family of enzymes found in the endoplasmic reticulum of cells and plays a crucial role in the metabolism of a wide range of endogenous and exogenous substances. These enzymes are responsible for the oxidation and biotransformation of drugs, toxins, and foreign compounds, making them more hydrophilic and easier to excrete from the body. Cytochrome P-450 enzymes are involved in the metabolism of many commonly used medications, and genetic polymorphisms in these enzymes can lead to variations in drug response and toxicity. Additionally, they are also involved in the synthesis of important endogenous compounds such as steroids, fatty acids, and prostaglandins, making them essential for normal physiological function.Check Digit Verification of cas no
The CAS Registry Mumber 12679-56-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,6,7 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.Calculate Digit Verification of CAS Registry Number 12679-56:
(7*1)+(6*2)+(5*6)+(4*7)+(3*9)+(2*5)+(1*6)=120
120 % 10 = 0
So 12679-56-0 is a valid CAS Registry Number.
12679-56-0Upstream product
12679-56-0Downstream Products
12679-56-0Related news
Male Wistar rats have been pretreated with either clofibrate or diethylhexylphthalate and the dose-dependency of induction of the microsomal, cytochrome P-452-driven fatty acid hydroxylase and peroxisomal fatty acid β-oxidation system investigated. Both clofibrate and DEHP specifically induced ...detailed
The gene coding for the clofibrate-induced cytochrome P-452 has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801–810] apart from the presence of an additional 75 nucleotides...detailed
Hepatocyte nodules, a characteristic early step in the development of liver cancer in rats, has a distinctive resistance phenotype including a large decrease in total cytochromes P-450 and in two isozymes induced by phenobarbital and two by 3-methylcholanthrene. In this study, it has been observ...detailed
The influence of four hypolipidaemic drugs (clofibrate, WY-14,643, clobuzarit and bezafibrate) on hepatic cytochrome P-450 and fatty acid metabolism in male rat liver microsomes has been investigated. All of the hypolipidaemic drugs tested significantly induced the hydroxylation of lauric acid a...detailed
Eight structurally diverse hypolipidaemic agents have been examined for their ability to induce the microsomal cytochrome P-452-dependent fatty acid hydroxylase system and the enzymes of peroxisomal β-oxidation in rat liver. Using a specific ELISA method, we have shown that the cytochrome P-452...detailed
We have examined the ability of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) to induce hepatic cytochrome P-452-linked enzyme activities in rat and pigeon liver five days after its intraperitoneal injection. The results provide evidence that, at the doses used, Aroclor 1254 i...detailed
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