12679-56-0

Usage

Uses

Used in Pharmaceutical Industry:
Cytochrome P-450 enzymes are used as biotransformation agents for the metabolism of drugs, ensuring that medications are effectively processed and rendered more hydrophilic for excretion. This helps in managing drug response and toxicity, as well as understanding the impact of genetic polymorphisms on drug efficacy.
Used in Toxicology Research:
In toxicology, cytochrome P-450 enzymes are utilized as biotransformation agents for the metabolism of toxins and foreign compounds, which is crucial for understanding their effects on the body and developing potential detoxification strategies.
Used in Endogenous Compound Synthesis:
Cytochrome P-450 enzymes are employed in the synthesis of important endogenous compounds, such as steroids, fatty acids, and prostaglandins, which are vital for maintaining normal physiological functions in the body.

Related news

Co-induction of microsomal cytochrome P-452 (cas 12679-56-0) and the peroxisomal fatty acid β-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate: Dose-response studies08/21/2019

Male Wistar rats have been pretreated with either clofibrate or diethylhexylphthalate and the dose-dependency of induction of the microsomal, cytochrome P-452-driven fatty acid hydroxylase and peroxisomal fatty acid β-oxidation system investigated. Both clofibrate and DEHP specifically induced ...detailed

Differential splicing in the 3′ non-coding region of rat cytochrome P-452 (cas 12679-56-0) (P450 IVA1) mRNA08/19/2019

The gene coding for the clofibrate-induced cytochrome P-452 has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801–810] apart from the presence of an additional 75 nucleotides...detailed

Decreased expression of cytochrome P-452 (cas 12679-56-0) in the resistance phenotype characteristic of putative preneoplastic hepatocyte nodules during hepatocarcinogenesis08/18/2019

Hepatocyte nodules, a characteristic early step in the development of liver cancer in rats, has a distinctive resistance phenotype including a large decrease in total cytochromes P-450 and in two isozymes induced by phenobarbital and two by 3-methylcholanthrene. In this study, it has been observ...detailed

Immunochemical study on the contribution of hypolipidaemic-induced cytochrome P-452 (cas 12679-56-0) to the metabolism of lauric acid and arachidonic acid08/17/2019

The influence of four hypolipidaemic drugs (clofibrate, WY-14,643, clobuzarit and bezafibrate) on hepatic cytochrome P-450 and fatty acid metabolism in male rat liver microsomes has been investigated. All of the hypolipidaemic drugs tested significantly induced the hydroxylation of lauric acid a...detailed

Microsomal cytochrome P-452 (cas 12679-56-0) induction and peroxisome proliferation by hypolipidaemic agents in rat liver: A mechanistic inter-relationship08/16/2019

Eight structurally diverse hypolipidaemic agents have been examined for their ability to induce the microsomal cytochrome P-452-dependent fatty acid hydroxylase system and the enzymes of peroxisomal β-oxidation in rat liver. Using a specific ELISA method, we have shown that the cytochrome P-452...detailed

Evidence for the induction of cytochrome P-452 (cas 12679-56-0) in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls08/15/2019

We have examined the ability of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) to induce hepatic cytochrome P-452-linked enzyme activities in rat and pigeon liver five days after its intraperitoneal injection. The results provide evidence that, at the doses used, Aroclor 1254 i...detailed