Differential splicing in the 3′ non-coding region of rat cytochrome P-452 (cas 12679-56-0) (P450 IVA1) mRNA

Add time:08/19/2019    Source:sciencedirect.com

The gene coding for the clofibrate-induced cytochrome P-452 (cas 12679-56-0) has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801–810] apart from the presence of an additional 75 nucleotides inserted adjacent to the 3′-end of the coding region. Northern blot analysis indicates that this is probably a consequence of differential splicing, which may be relevant to the tissue-specific regulation of this gene.

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