126799-93-7Relevant academic research and scientific papers
1,2,3-triazolo [4,5-d] pyridazines-V. Preparation and adenosine receptor binding of new 4-amino derivatives
Biagi,Giorgi,Livi,Manera,Scartoni,Lucacchini,Senatore
, p. 601 - 608 (2007/10/03)
This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyridazine derivatives which had shown binding affinity towards A1-adenosine receptors. 1-Benzyl derivatives bearing new amines and new 1-(substituted benzyl) derivatives were prepared and tested. The biological results showed that some compounds possessed high affinity (~30-70 nM) and good selectivity toward the A1-adenosine receptors. Further information about structure-biological activity relationships was acquired.
Dipolar Cycloaddition Reactions of Organic Azides with some Acetylenic Compounds
Abu-Orabi, Sultan T.,Atfah, M. Adnan,Jibril, Ibrahim,Mari'i, Fakhri M.,Ali, Amer Al-Sheikh
, p. 1461 - 1468 (2007/10/02)
Phenyl azide 1 and several substituted benzyl azides 2a-o underwent 1,3-dipolar cycloaddition reactions with dimethyl acrtylenedicarboxylate 3, phenylacetylene 4 and ethyl propiolate 5 to afford the triazoles 6-13.The reactions of these azides with ethyl
