126806-65-3Relevant academic research and scientific papers
Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative
Shigyo,Sato,Shibuya,Takahashi,Yamaguchi,Sonoki,Ohta
, p. 1573 - 1582 (2007/10/02)
A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3- aminobutyramido)-4-(2,2,2-trifluoroethoxy)phenyl]pyridines (23h, 24h) and 3- [2-(3-aminobutyramido)-4-ethoxyphenyl]pyridine (24i) showed potent antiarrhythmic activity. They had approximately twice the potency of mexiletine (III). Compound 24i was selected from this series as a candidate for further development; it was found to have a class I B electrophysiological character and to show a slow kinetic rate-dependent block (RDB) of the sodium channel in cardiac muscle.
A FACILE SYNTHESIS OF 3-(2-AMINO-4-ETHOXYPHENYL)PYRIDINE
Shibuya, Kimiyuki,Shigyo, Hiromichi,Ohta, Tomio
, p. 427 - 433 (2007/10/02)
A facile and efficient synthesis of 3-(2-amino-4-ethoxyphenyl)pyridine (6), a key intermediate of the antiarrhythmic agents, has been developed starting from 3-bromopyridine (2) by the benzyne reaction using sodium benzylamide as the key step.
