4373-75-5

Upstream product

• 1120-90-7 3-iodopyridine 
• 5344-78-5 4-bromo-3-nitroanizole 
• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 
• 1692-25-7 3-pyridylboronic acid 
• 110-86-1 pyridine 
• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 158461-52-0 5-methoxy-2-pyridin-3-ylphenylamine 
• 119289-79-1 3-(4-hydroxy-2-nitrophenyl)pyridine 
• 158461-83-7 [2-(5-Hydroxy-2-pyridin-3-yl-phenylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester 
• 158461-78-0 [2-(5-Methoxy-2-pyridin-3-yl-phenylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester 
• 158461-88-2 N-(5-Allyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide 
• 158461-87-1 N-(5-Isopropoxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide 
• 158461-86-0 N-(5-Propoxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide 
• 119289-82-6 {1-[2-Pyridin-3-yl-5-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 158461-84-8 {1-Methyl-2-[2-pyridin-3-yl-5-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 158461-89-3 N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide 
• 158461-43-9 3-(2-nitro-4-n-octyloxyphenyl)pyridine 
• 139085-99-7 3-<4-ethoxy-2-(N-TFA-3-aminobutyramido)phenyl>pyridine 
• 119289-80-4 3-<2-nitro-4-(2,2,2-trifluoroethoxy)phenyl>pyridine 

Relevant academic research and scientific papers

Synthesis of nitrogen heterocycles by the ring opening of pyridinium salts

(Chemical Equation Presented) The century-old ring-opening reaction of pyridinium salts with tethered nucleophiles has been harnessed for a synthesis of substituted indoles and related nitrogen heterocyles. Extension of this method could lead to oxygen- and sulfur-containing heterocycles and carbocycles, as well as to applications in natural product synthesis and medicinal chemistry.

Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative

A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3- aminobutyramido)-4-(2,2,2-trifluoroethoxy)phenyl]pyridines (23h, 24h) and 3- [2-(3-aminobutyramido)-4-ethoxyphenyl]pyridine (24i) showed potent antiarrhythmic activity. They had approximately twice the potency of mexiletine (III). Compound 24i was selected from this series as a candidate for further development; it was found to have a class I B electrophysiological character and to show a slow kinetic rate-dependent block (RDB) of the sodium channel in cardiac muscle.

A simple and efficient synthesis of 2,- 3-, or 4-(2-nitrophenyl)pyridine derivatives via palladium catalyzed ullmann cross-coupling reaction

The Ullmann cross-coupling reaction of halopyridines with 2-bromonitirobenzenes was successffully catalyzed by low valent palladium [Pd(PPh3)4, PdCl2(PPh3)2, PdCl2] to afford (2-nitrophenyl)pyridine derivatives in good to excellent yield.