1268157-49-8

Basic information

• Product Name: N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-D,L-tyrosinamide
• CAS NO: 1268157-49-8
• Molecular Weight: 442.409
• Mol File: 1268157-49-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-D,L-tyrosinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-D,L-tyrosinamide(1268157-49-8)
• EPA Substance Registry System: N-acetyl-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-O-phosphono-D,L-tyrosinamide(1268157-49-8)

Safety Data

• Hazardous Substances Data: 1268157-49-8(Hazardous Substances Data)

Upstream product

• 2901-77-1 N-acetyltyrosine 

Relevant articles and documents

Development of non-peptide ligands of growth factor receptor-bound protein 2-src homology 2 domain using molecular modeling and NMR spectroscopy

We report a novel series of non-peptide ligands that inhibit the growth factor receptor-bound protein 2 (Grb2)-Src homology 2 (SH2) domain binding, designed using a combined computational and NMR-driven approach. We have identified a new lead compound, 1n (IC50 = 56 μM), which is cytotoxic in HER2-positive breast cancer cells and disrupts the interaction between HER2 and Grb2. Thus, 1n can be used as a scaffold for the development of efficient Grb2-SH2 domain binding inhibitors.