1268265-24-2

Upstream product

• 89-82-7 pulegone 
• 7712-68-7 (1S,5R)-trans-pulegenic acid 
• 7712-70-1 ((1S)-2-isopropylidene-5t-methyl-cyclopent-r-yl)-methanol 
• 33066-20-5 (E)-1-isocyanato-2-phenylethene 
• 1268265-17-3 3-((1R,4S,5R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2,5-dimethylcyclopent-2-en-1-yl)-4-hydroxy-5-phenylpyridin-2(1H)-one 
• 1268265-23-1 ethyl 2-((1S,4S,5R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2,5-dimethylcyclopent-2-en-1-yl)-3-oxo-3-((E)-styrylamino)propanoate 
• 1268265-18-4 (E)-ethyl 3-oxo-3-(styrylamino)propanoate 
• 1268265-19-5 (1S,4R,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-2,4-dimethylcyclopent-2-en-1-yl methyl carbonate 
• 1268265-22-0 (1S,4R,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-2,4-dimethylcyclopent-2-enol 
• 1268265-21-9 (4R,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-2,4-dimethylcyclopent-2-enone 
• 1268265-30-0 (4S,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-4-methylcyclopent-2-enone 
• 1268265-20-8 (4R,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-4-methylcyclopent-2-enone 
• 876152-54-4 tert-butyl(((1S,2R)-2-methyl-5-(propan-2-ylidene)cyclopentyl)methoxy)diphenylsilane 
• 876152-36-2 (2R,3R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3-methylcyclopentanone 

Downstream Products

• 1268265-26-4 (5aR,6R,7R,8R,8aS)-7-(hydroxymethyl)-6-iodo-5a,8-dimethyl-4-phenyl-2,5a,6,7,8,8a-hexahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridin-1-one 
• 1268265-27-5 (5aS,8R,8aS)-5a,8-dimethyl-1-oxo-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carbaldehyde 
• 1268265-28-6 (5aS,8R,8aS)-7-(1,3-dithiolan-2-yl)-5a,8-dimethyl-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridin-1-one 
• 864448-19-1 (5aS,8R,8aS)-5a,7,8-trimethyl-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridin-1-one 
• 1268265-29-7 (5aS,8R,8aS)-1-(methoxymethoxy)-5a,7,8-trimethyl-4-phenyl-8,8a-dihydro-5aH-cyclopenta[4,5]furo[3,2-c]pyridine 
• 1616975-81-5 (5aS,8R,8aS)-7-(hydroxymethyl)-5a,8-dimethyl-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridin-1-one 
• 1616975-78-0 (5aS,8S,8aS)-5a,8-dimethyl-4-phenyl-2,5a,8,8a-tetrahydro-1H-cyclopenta[4,5]furo[3,2-c]pyridin-1-one 

Relevant academic research and scientific papers

Synthesis and biological activity of Citridone A and its derivatives

Citridone A (1), originally isolated as a potentiator of antifungal miconazole activity from a fungal culture broth, has a phenyl-R-furopyridone structure. Because of its unique ring structure, 11 derivatives were chemically synthesized and their biological activity was evaluated. Derivatives 17, 20 and 21 potentiated miconazole activity against Candida albicans. Furthermore, 1, 14, 20 and 21 were found to inhibit yellow pigment production in methicillin-resistant Staphylococcus aureus.

Total synthesis of citridone A

The first total synthesis of citridone A has been achieved through regioselective intramolecular iodocyclization and regio-and stereoselective Pd(0)-catalyzed coupling as key reactions.(Figure Presented)