1268265-99-1

Basic information

• Product Name: N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide
• Synonyms: N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide
• CAS NO: 1268265-99-1
• Molecular Weight: 280.348
• Mol File: 1268265-99-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide(1268265-99-1)
• EPA Substance Registry System: N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide(1268265-99-1)

Safety Data

• Hazardous Substances Data: 1268265-99-1(Hazardous Substances Data)

Upstream product

• 1200070-42-3 2-(4-amino-3-iodo-phenyl)ethanesulfonic acid methylamide 
• 1268265-95-7 N-[4-(2-{methylsulfamoyl}ethyl)-2-{2-(trimethylsilanyl)ethynyl}phenyl]acetamide 
• 1268265-90-2 N-[2-iodo-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide 
• 98623-16-6 2-(4-amino-phenyl)ethanesulfonic acid methylamide 

Downstream Products

• 143388-64-1 naratriptan hydrochloride 
• 98623-50-8 N-Methyl-1H-indole-5-ethanesulphonamide 
• 121679-13-8 naratriptan 
• 121679-20-7 N-methyl-2-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide 

Relevant articles and documents

A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN

The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z'' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.