126827-40-5

Upstream product

• 126827-27-8 2-methylthio-4-phenyl-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidinium iodide 
• 126827-25-6 2-thioxo-4-phenyl-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 100-52-7 benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 126827-29-0 methyl 1,4-dimethyl-2-(methylthio)-6-phenyl-1,6-dihydropyrimidine-5-carboxylate 
• 126827-41-6 1,6-Dimethyl-2-methylsulfanyl-4-phenyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester 
• 1619238-01-5 methyl 4-methyl-2-(methylthio)-6-phenylpyrimidine-5-carboxylate 
• 126827-33-6 5-methoxycarbonyl-6-methyl-4-phenyl-1,4-dihydropyrimidine 

Relevant academic research and scientific papers

Reduction of Biginelli compounds by LiAlH4: a rapid access to molecular diversity

Herein, the reduction of Biginelli compounds by LiAlH4 was investigated for the first time. The reduction of urea-derived dihydropyrimidinones yielded 80-95% of hydrogenolysis products (4-aryl-5-(m)ethyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones

Synthesis of 2-substituted pyrimidines and benzoxazoles via a visible-light-driven organocatalytic aerobic oxidation: Enhancement of the reaction rate and selectivity by a base

An efficient visible-light-driven photocatalytic oxidation of various 2-substituted dihydropyrimidines and phenolic imines has been achieved using an organic photocatalyst eosin Y bis(tetrabutyl ammonium salt) (TBA-eosin Y) and inexpensive oxidant molecular oxygen. With the aid of a base, significantly enhanced photoinduced electron transfer from substrates dihydropyrimidines or phenolic imines to the excited state of TBA-eosin Y has enabled the aerobic oxidation to yield 2-(methylthio)pyrimidines or 2-arylbenzoxazoles selectively. This journal is the Partner Organisations 2014.

Synthesis, molecular docking, and cardioprotective activity of 2-methylthio-1,4-dihydropyrimidines

A series of 2-methylthio-1,4-dihydropyrimidine derivatives (IIa-IIl) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (Ia-Il) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analys

Reactions with hydrazonoyl halides 45: Synthesis of some new triazolino [4,3-a]pyrimidines, pyrazolo [3,4-d]pyridazines, isoxazolo[3,4-d]pyridazines, and thieno[2,3-b]pyridines

Triazolino[4,3-α]pyrimidines pyrazolo[3,4-d]pyridazines and isoxazolo[3,4-d] pyridazines were synthesized from hydrazonoyl halides. Also, 3-aminothieno[2,3-b] pyridines and pyrimidino[4′,5′:4,5]thieno[2,3- b]pyridines were synthesized from cynothioacetamide. Structures of the newly synthesized compounds were established on the basis of elemental analyses and spectral data. Copyright Taylor & Francis LLC.

ALKYLATION AND REDUCTIVE DETHIONATION OF 2-THIOXO- AND 1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLIC ACID DERIVATIVES

2-Methylthio-1,4-dihydropyrimidines were obtained by methylation of 2-thioxo-4-phenyl-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine or its 1-methyl derivative in a neutral medium.The alkylation of tetrahydropyrimidine-2-thiones in the anionic fo