1268465-08-2

Upstream product

• 127152-98-1 benzyl 2-(4-bromophenyl)acetate 
• 73183-34-3 bis(pinacol)diborane 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 1268465-09-3 benzyl 2-(4-((1E,4E)-2-amino-4-(dipropylcarbamoyl)-3H-benzo[b]azepin-8-yl)phenyl)acetate 
• 1421009-33-7 2'-(2-hydroxyethoxy)-5'-methyl-[1,1':3',1-terphenyl]-4,4-diacetic acid dibenzyl ester 

Relevant academic research and scientific papers

Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton

Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphe

SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.