1268471-41-5Relevant academic research and scientific papers
Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464
Osman, Sami,Albert, Brian J.,Wang, Yanping,Li, Miaosheng,Czaicki, Nancy L.,Koide, Kazunori
, p. 895 - 904 (2011)
FR901464, a natural product isolated from a bacterium source, activates a reporter gene, inhibits pre-mRNA splicing, and shows antitumor activity. We previously reported the development of a more potent analogue, meayamycin, through the total synthesis of
