1268526-06-2Relevant articles and documents
Near-infrared pH probes based on phenoxazinium connecting with nitrophenyl and pyridinyl groups
Zhu, Wei-Jin,Niu, Jin-Yun,He, Dan-Dan,Sun, Ru,Xu, Yu-Jie,Ge, Jian-Feng
, p. 481 - 490 (2018)
Three phenoxazinium compounds attached with o-nitrophenyl (3a), m-nitrophenyl (3b) and p-nitrophenyl (3c) groups were prepared, and the pH promoted emission spectra were used to evaluate the deprotonated-protonated equilibrium between phenoxazinium and phenoxazine. They showed nearly ON-OFF emission responses at 650–850 nm around pH 8.0–10.8, and the fluorescence related pKas of 3a–c were 8.7, 9.2, and 8.9, respectively. Two phenoxazinium compounds attached with pyridinyl groups (7a–b) were further prepared, the pH promoted emission spectra were influenced by both the deprotonated-protonated equilibrium between phenoxazinium and phenoxazine, and the equilibrium between pyridinyl group and pyridinumyl group. They exhibited more strong red and near-infrared emission at 600–850 nm, probe 7a gave pKa,1 = 3.71 and pKa,2 = 9.68, and that of probe 7b was 2.75. Moreover, the fluorescent imaging experiment indicated that probe 7a was a lysosome biomarker for V79 and HeLa cells.
Carbene adduct of cyclopalladated ferrocenylimine-assisted synthesis of aminopyridine derivatives by the amination of chloropyridines with primary and secondary amines
Mu, Bing,Li, Jingya,Wu, Yangjie
, p. 537 - 541 (2013/09/23)
An efficient, simple way to synthesize aminopyridine derivatives is presented, based on Buchwald-Hartwig aminations. Using 1 mol% N-heterocyclic carbene adduct of cyclopalladated ferrocenylimine in the presence of 1.5 equiv. tBuOK as base in dioxane at 110°C offered moderate to excellent yields in the reaction of chloropyridines with primary and secondary amines, including sterically hindered amines and alkyl amines. Copyright
Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens
Mazu, Tryphon K.,Etukala, Jagan R.,Zhu, Xue Y.,Jacob, Melissa R.,Khan, Shabana I.,Walker, Larry A.,Ablordeppey, Seth Y.
experimental part, p. 524 - 533 (2011/02/28)
Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived.
