1268526-22-2Relevant academic research and scientific papers
Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens
Mazu, Tryphon K.,Etukala, Jagan R.,Zhu, Xue Y.,Jacob, Melissa R.,Khan, Shabana I.,Walker, Larry A.,Ablordeppey, Seth Y.
experimental part, p. 524 - 533 (2011/02/28)
Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived.
