1268622-77-0Relevant academic research and scientific papers
An M2-V27A channel blocker demonstrates potent in?vitro and in?vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses
Hu, Yanmei,Musharrafieh, Rami,Ma, Chunlong,Zhang, Jiantao,Smee, Donald F.,DeGrado, William F.,Wang, Jun
, p. 45 - 54 (2017/01/25)
Adamantanes such as amantadine (1) and rimantadine (2) are FDA-approved anti-influenza drugs that act by inhibiting the wild-type M2 proton channel from influenza A viruses, thereby inhibiting the uncoating of the virus. Although adamantanes have been suc
ADAMANTANE ANALOGS
-
, (2011/04/13)
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
