1268636-17-4

Upstream product

• 52010-96-5 3-(hydroxy(phenyl)methyl)benzaldehyde 
• 579-18-0 3-benzoylbenzoic acid 
• 1268604-44-9 (Z)-1-acetyl-3-((5-(2-methylpent-4-yn-2yl)oxazol-4-yl)methylene)piperazine-2,5-dione 
• 71856-95-6 3-benzoylbenzaldehyde 
• 422550-77-4 3-benzoyl-N-methoxy-N-methylbenzamide 
• 1268604-43-8 5-(2-methylpent-4-yn-2-yl)oxazole-4-carboaldehyde 
• 1268604-42-7 ethyl 5-(2-methylpent-4-yn-2-yl)oxazole-4-carboxylate 
• 1268604-41-6 C₁₀H₁₃NO₂ 
• 1092173-29-9 N-D-biotinyl-Acp-Acp-amino-propylazide 
• 1268604-45-0 (3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione 

Relevant academic research and scientific papers

Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole

A new bioactive photoaffinity probe KPU-252-B1 (4) possessing a biotin tag on the oxazole ring of a potent plinabulin derivative KPU-244 (2) was synthesized via the CuI-catalyzed Huisgen's cycloaddition reaction to understand the precise binding mode of the diketopiperazine-based anti-microtubule agent plinabulin on tubulin. Probe 4 showed significant binding affinity toward tubulin and cytotoxicity against an HT-29 cells. A photoaffinity labeling study suggested that probe 4 specifically recognizes tubulin at a binding site that binds plinabulin or colchicine, most likely near or at the colchicine binding site, which is located at the interfacial region formed by α-and β-tubulin association. The results also demonstrated that probe 4 may serve as a useful plinabulin chemical probe to investigate the molecular mechanism by which anti-microtubule diketopiperazine derivatives operate.