1268684-06-5

Upstream product

• 2106-04-9 3-chloro-2-fluoroaniline 

Downstream Products

• 1268684-02-1 C₂₃H₂₈ClFN₂O₂Si 
• 1268680-63-2 1-(6-carboxymethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 1268684-03-2 C₁₈H₁₉ClFIN₂O₂ 
• 1268684-01-0 C₂₀H₂₂ClFN₂O₄ 
• 1268684-00-9 C₂₀H₂₁BrClFN₂O₄ 
• 1268680-66-5 1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 1268680-69-8 1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid 
• 1268680-89-2 C₂₈H₃₀Cl₂F₂N₄O₃ 
• 1268684-05-4 C₁₃H₁₅ClFIN₂ 

Relevant academic research and scientific papers

Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction

Capitalizing on crystal structure information obtained from a previous effort in the search for non peptide inhibitors of the p53-MDM2 interaction, we have discovered another new class of compounds able to disrupt this protein-protein interaction, an important target in oncology drug research. The new inhibitors, based on a tetra-substituted imidazole scaffold, have been optimized to low nanomolar potency in a biochemical assay following a structure-guided approach. An appropriate strategy has allowed us to translate the high biochemical potency in significant anti-proliferative activity on a p53-dependent MDM2 amplified cell line.

CONDENSED HETEROCYCLIC COMPOUND

A compound represented by the general formula (I) [R1 represents a C1-6 alkyl group, a halogen atom, or the like; A represents a phenylene group, or the like; X represents —CH(R3)—, —O—, —NH—, or the like; Y represents —O—, —NH—, —N═, or —S—; . . . represents a single bond or double bond; n represents 1 to 3; R2 represents a C1-6 alkyl group, a C1-6 alkoxy group, or the like; and R3 represents hydrogen atom, a C1-6 alkyl group, or the like], or a salt thereof which has a blood LDL cholesterol-reducing action, and is useful as an active ingredient of medicaments.