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CAS

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1268720-50-8

N1-(1,2,3,4-tetrahydroacridin-9-yl)-N6-(3,4,5-trimethoxybenzyl)hexane-1,6-diamine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1268720-50-8 Structure

  • Basic information

    1. Product Name: N1-(1,2,3,4-tetrahydroacridin-9-yl)-N6-(3,4,5-trimethoxybenzyl)hexane-1,6-diamine
    2. Synonyms: N1-(1,2,3,4-tetrahydroacridin-9-yl)-N6-(3,4,5-trimethoxybenzyl)hexane-1,6-diamine
    3. CAS NO:1268720-50-8
    4. Molecular Formula:
    5. Molecular Weight: 477.647
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1268720-50-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N1-(1,2,3,4-tetrahydroacridin-9-yl)-N6-(3,4,5-trimethoxybenzyl)hexane-1,6-diamine(CAS DataBase Reference)
    10. NIST Chemistry Reference: N1-(1,2,3,4-tetrahydroacridin-9-yl)-N6-(3,4,5-trimethoxybenzyl)hexane-1,6-diamine(1268720-50-8)
    11. EPA Substance Registry System: N1-(1,2,3,4-tetrahydroacridin-9-yl)-N6-(3,4,5-trimethoxybenzyl)hexane-1,6-diamine(1268720-50-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1268720-50-8(Hazardous Substances Data)

1268720-50-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1268720-50-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,8,7,2 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1268720-50:
(9*1)+(8*2)+(7*6)+(6*8)+(5*7)+(4*2)+(3*0)+(2*5)+(1*0)=168
168 % 10 = 8
So 1268720-50-8 is a valid CAS Registry Number.

1268720-50-8Downstream Products

1268720-50-8Relevant articles and documents

Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation

Luo, Wen,Li, Yan-Ping,He, Yan,Huang, Shi-Liang,Tan, Jia-Heng,Ou, Tian-Miao,Li, Ding,Gu, Lian-Quan,Huang, Zhi-Shu

, p. 763 - 770 (2011)

A new series of tacrine-multialkoxybenzene hybrids (9a-9n) were designed, synthesized and evaluated as dual inhibitors of cholinesterases (ChEs) and self-induced β-amyloid (Aβ) aggregation. All the synthesized compounds had high acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity with IC50 values at the nanomolar range, which were much better than tacrine alone. A Lineweaver-Burk plot and molecular modeling study showed that these hybrids targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Besides, compounds 9a-9f with methylenedioxybenzene moiety showed higher self-induced Aβ aggregation inhibitory activity than a reference compound, curcumin. These compounds could be selected as multi-potent agents for further investigation to treat AD.

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