126899-02-3

Upstream product

• 117872-98-7 triethylammonium hypophosphite 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 118352-75-3 Triethylammonium 6-N-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-H-phosphonate 
• 121-44-8 triethylamine 

Relevant academic research and scientific papers

Silylation-mediated transesterification of O-phenyl H-phosphonothioates - A new entry to nucleoside H-phosphonothioate monoesters

O-Phenyl H-phosphonothioate undergoes a facile transesterification with suitably protected nucleosides upon in situ silylation with tert- butyldiphenylsilyl chloride in pyridine/toluene to produce the corresponding 3′-H-phosphonothioates in good yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Aryl H-Phosphonates. 12. Synthetic and 31P NMR Studies on the Preparation of Nucleoside H-Phosphonothioate and Nucleoside H-Phosphonodithioate Monoesters

Transformation of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioate and H-phosphonodithioate derivatives and possible side-reactions that may accompany this process were studied using 31P NMR spectroscopy. These provided new insight into a possible mechanism involved in this transformation and constituted the basis for development of efficient methods for the preparation of nucleoside H-phosphonothioate and nucleoside H-phosphonodithioate monoesters using readily available H-phosphonate monoesters as starting materials.