126900-01-4Relevant academic research and scientific papers
Total synthesis of calicheamicinone: New arrangements for actuation of the reductive cycloaromatization of aglycon congeners
Haseltine, John N.,Cabal, Maria Paz,Mantlo, Nathan B.,Iwasawa, Nobuharu,Yamashita, Dennis S.,Coleman, Robert S.,Danishefsky, Samuel J.,Schulte, Gayle K.
, p. 3850 - 3866 (2007/10/02)
The total synthesis of dl-calicheamicinone (1) has been accomplished. The key elements of the synthesis were (i) an application of the Becker-Adler reaction to reach compound 91, (ii) an application of the concept of in situ protection to deliver lithiate
Installation of the Allylic Trisulfide Functionality of the Enediyne Antibiotics. Thiol-Induced Reductive Actuation of the Bergman Process
Haseltine, John N.,Danishefsky, Samuel J.
, p. 2576 - 2578 (2007/10/02)
The title compounds were synthesized through thiosulfenylation.Exposure of the trisulfides to benzyl mercaptan induced reductive cycloaromatization.
