1269026-22-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate is used as a pharmaceutical agent for inhibiting SHP2 activity. SHP2 is a protein tyrosine phosphatase that plays a crucial role in various cellular processes, including signal transduction and cell growth. Inhibition of SHP2 activity has been shown to have therapeutic potential in the treatment of various diseases, such as cancer and inflammatory disorders.
Used in Cancer Therapy:
In the field of cancer therapy, ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate is employed as an inhibitor of SHP2 activity. By targeting this enzyme, it can potentially disrupt the signaling pathways that promote tumor growth and progression. This makes it a promising candidate for the development of novel anticancer drugs.
Used in Inflammatory Disease Treatment:
Ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate can also be used in the treatment of inflammatory diseases. SHP2 has been implicated in the regulation of inflammatory responses, and its inhibition can help reduce inflammation and alleviate symptoms associated with various inflammatory conditions.

Upstream product

• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 105-53-3 diethyl malonate 
• 141872-22-2 ethyl 2-hydroxy-6-methylpyrazine-3-carboxylate 
• 609-09-6 Diethyl ketomalonate 

Downstream Products

• 1269028-02-5 ethyl 3-(benzyloxy)-6-bromo-5-methylpyrazine-2-carboxylate 
• 1269026-24-5 ethyl 3-hydroxy-5-methyl-6-phenylpyrazine-2-carboxylate 
• 2172651-73-7 {3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl}methanol 

Relevant academic research and scientific papers

REGULATOR OF NITROGEN-CONTAINING HETEROAROMATIC DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a regulator of nitrogen-containing heteroaromatic derivatives, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer, wherein the definition of each substituent in the general formula (I) is the same as that in the description.

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

Provided is a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided is a pharmaceutical composition comprising the said compound.

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF

The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.