1269026-22-3

Basic information

• Product Name: ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate
• Synonyms: ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate
• CAS NO: 1269026-22-3
• Molecular Weight: 261.075
• Mol File: 1269026-22-3.mol
• Article Data: 6

Chemical Properties

• Density: 1.69±0.1 g/cm3(Predicted)
• CAS DataBase Reference: ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate(1269026-22-3)
• EPA Substance Registry System: ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate(1269026-22-3)

Safety Data

• Hazardous Substances Data: 1269026-22-3(Hazardous Substances Data)

Usage

Uses

Ethyl 6-Bromo-3,4-dihydro-5-methyl-3-oxo-2-pyrazinecarboxylate can be used to inhibit SHP2 activity.

Upstream product

• 105-53-3 diethyl malonate 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 141872-22-2 ethyl 2-hydroxy-6-methylpyrazine-3-carboxylate 
• 609-09-6 Diethyl ketomalonate 

Downstream Products

• 1269028-02-5 ethyl 3-(benzyloxy)-6-bromo-5-methylpyrazine-2-carboxylate 
• 2172651-73-7 {3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl}methanol 
• 1269026-24-5 ethyl 3-hydroxy-5-methyl-6-phenylpyrazine-2-carboxylate 

Relevant articles and documents

REGULATOR OF NITROGEN-CONTAINING HETEROAROMATIC DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a regulator of nitrogen-containing heteroaromatic derivatives, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer, wherein the definition of each substituent in the general formula (I) is the same as that in the description.

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.