126909-78-2

Usage

Type of compound

brominated aromatic compound

Structure

contains a benzene ring with a bromine atom attached at the 1 position and a cyclopropylmethoxy group attached at the 3 position

Functional groups

bromine atom, aromatic ring, cyclopropylmethoxy group

Applications

useful building block in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals

Versatility

the cyclopropylmethoxy group adds further versatility to 1-Bromo-3-(cyclopropylmethoxy)benzene as a synthetic building block

Potential applications

development of new materials, research tool in organic chemistry

Upstream product

• 186581-53-3 diazomethane 
• 41388-50-5 1-(allyloxy)-3-bromobenzene 
• 591-20-8 3-Bromophenol 
• 7051-34-5 cyclopropylcarbinyl bromide 

Downstream Products

• 1198223-21-0 C₁₅H₂₂O₂ 
• 1198223-20-9 3-(3-(cyclopropylmethoxy)phenyl)pentan-3-amine 
• 1198223-22-1 C₁₅H₂₁N₃O 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold

The free fatty acid receptor 1 (FFA1/GPR40) and peroxisome proliferator-activated receptor δ (PPARδ) have been widely considered as promising targets for type 2 diabetes mellitus (T2DM) due to their respective roles in promoting insulin secretion and impr

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

AMINO SULFONYL COMPOUNDS

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

Palladium(II)-Catalyzed Cyclopropanation of Simple Allyloxy and Allylamino Compounds and of 1-Oxy-1,3-butadienes with Diazomethane

(Alkyloxymethyl)-, (aminomethyl)-, (2-alkoxyethenyl)-, (2-acetoxyethenyl)-, and (2-siloxyethenyl)cyclopropanes are obtained in high yields by reaction of allyl alcohol or derivatives, allylamines, 1-alkoxy-, 1-acetoxy-, and 1-trimethylsiloxy-1,3-butadienes with diazomethane in dichloromethane/diethylether in the presence of bis(benzonitrile)palladium dichloride.

REACTIONS OF DIAZOALKANES WITH UNSATURATED COMPOUNDS. 8. CATALYTIC CYCLOPROPANATION OF ALLYL ALCOHOLS AND ALLYLAMINES WITH DIAZOMETHANE

Allyl alcohols and allylamines have been cyclopropanated directly with diazomethane in the presence of palladium compounds to give 60-88percent of cyclopropylmethanols and cyclopropylmethylamines, respectively, almost free from the products of formal insertion of methylene into the heteroatom-hydrogen bond.