126910-75-6

Upstream product

• 17193-39-4 methyl 3-cyclohexyl-L-alaninate hydrochloride 
• 126910-82-5 (S)-α-<(3-ethoxy-1,3-dioxopropyl)amino>cyclohexanepropanoic acid, methyl ester 
• 126910-73-4 (S)-5-(cyclohexylmethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrole-3-carboxylic acid, ethyl ester 

Downstream Products

• 126910-76-7 (4S-cis)-5-(cyclohexylmethyl)-4-hydroxy-2-pyrrolidinone 
• 126910-79-0 <4S(RS),5S>-5-(cyclohexylmethyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-oxo-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester 
• 126910-77-8 <4S(RS),5S>-5-(cyclohexylmethyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinone 
• 105192-90-3 ACHPA 

Relevant academic research and scientific papers

2-oxo-1-pyrrolidine carboxylic acid esters

An improved process for the preparation of statine, the phenyl analog of statine, the cyclohexyl analog of statine and derivatives thereof is described, as well as other valuable intermediates used in the process.

STEREOSPECIFIC SYNTHESIS OF S,S-STATINE AND ITS CONGENERS

Statine, (STA, 8) and its cyclohexyl analog (ACHPA, 9) are obtained by a stereospecific synthesis via tetramic acid chemistry.Amides of STA and ACHPA, useful for the synthesis of antihypertensive renin inhibitors, are prepared directly from the intermedia

PROCESS FOR STATINE AND STATINE ANALOGS

An improved process for the preparation of statine, the phenyl analog of statine, the cyclohexyl analog of statine and derivatives thereof is described, as well as other valuable intermediates used in the process.