1269142-40-6Relevant articles and documents
Benzoylureas as removable cis amide inducers: Synthesis of cyclic amides via ring closing metathesis (RCM)
Brady, Ryan M.,Khakham, Yelena,Lessene, Guillaume,Baell, Jonathan B.
, p. 656 - 658 (2011/03/22)
Rapid and high yielding synthesis of medium ring lactams was made possible through the use of a benzoylurea auxiliary that serves to stabilize a cisoid amide conformation, facilitating cyclization. The auxiliary is released after activation under the mild conditions required to deprotect a primary amine, such as acidolysis of a Boc group in the examples given here. This methodology is a promising tool for the synthesis of medium ring lactams, macrocyclic natural products and peptides.
