126918-28-3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 137035-03-1 [(2S,3R)-2-(2,4-Difluoro-phenyl)-3-methyl-oxiranyl]-methanol 
• 136926-11-9 Methanesulfonic acid (1S,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-but-3-enyl ester 
• 137035-04-2 (2R,3R)-2-(2,4-Difluoro-phenyl)-3-methyl-2-vinyl-oxirane 
• 137035-05-3 (2R,3R)-2-(2,4-Difluoro-phenyl)-3-methyl-oxirane-2-carbaldehyde 

Downstream Products

• 135270-07-4 (2S,3R)-2-(2,4-difluorophenyl)-3-methyl-2-<(1H-1,2,4-triazol-1-yl)methyl>oxirane 

Relevant academic research and scientific papers

Payne rearrangement route to the optically active oxirane precursor for the preparation of triazole antifungals

Optically active epoxide 1, an important intermediate for the preparation of antifungal triazole-amides 2, was synthesized starting from the (S)-lactic acid-derived ketone 9 and taking advantage of the Payne rearrangement of the epoxyalcohol 8.