126922-61-0

Usage

Uses

Used in Research Studies:
Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]is used as a research tool for studying the structure and function of nucleic acids. Guanosine,
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]
-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-'s unique modifications allow researchers to investigate its interactions with other biomolecules and its potential role in various biological processes.
Used in Drug Development:
In the pharmaceutical industry, Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]is used as a starting material for the development of nucleoside analogs. These analogs have the potential to target specific enzymes or pathways involved in diseases, offering new therapeutic options for various conditions.
Used in Diagnostic Applications:
Guanosine,
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]
-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-'s unique structure and modifications make it a valuable tool in the development of diagnostic assays and tests. Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]can be used to design probes or markers that specifically recognize and bind to target nucleic acid sequences, enabling accurate detection and analysis of genetic information.
Used in Biochemical Reagents:
Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]can also be employed as a biochemical reagent in various laboratory applications. Its unique properties make it suitable for use in enzyme assays, nucleic acid synthesis, and other biochemical processes that require stable and functional nucleoside analogs.

Upstream product

• 126922-63-2 2'-O-(tert-butyldimethylsilyl)-2-N-(dimethylaminomethylene)guanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 401812-99-5 2'-O-(tert-butyldimethylsilyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine 
• 118-00-3 G 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 827602-95-9 N²-(dimethylaminomethylene)-2'-O-(tert-butyldimethylsilyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 149559-87-5 N²-(dimethylaminomethylene)-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)guanosine 3'-[(2-cyanoethyl)-N,N-diisopropylaminophosphoramidite] 
• 137760-78-2 C₄₀H₅₁N₆O₉PSi*C₆H₁₅N 

Relevant academic research and scientific papers

Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase

Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of separating the compound and product peaks with good resolution was optimized and applied to the analysis of the compounds. Results obtained show that cyclic di-inosinylic acid 1b demonstrates a stronger inhibition on Slr1143 than c-di-GMP and is a potential inhibitor for biofilm formation.

An improved method for synthesizing cyclic bis(3′-5′)diguanylic acid (c-di-GMP)

This paper describes a new method for synthesizing biologically important cyclic bis(3′-5′)diguanylic acid (c-di-GMP) in a higher yield than that previously reported to be available by our synthetic method. In the new synthesis, the following two means, i

DIMETHYLAMINOMETHYLENE PROTECTED PURINE H-PHOSPHONATES IN THE SYNTHESIS OF BIOLOGICALLY ACTIVE RNA (24-MER)

Preparation of 5'-O-(4,4'-dimethoxytrityl)-2'-O-tert-butyldimethylsilyl (tBDMSi) derivatives of N2-dimethylaminomethyleneguanosine (IIIa) and N6-dimethylaminomethyleneadenosine (IVa) and their 3'-H-phosphonates (IIIb, IVb) is described.The compounds IIIb and IVb together with corresponding derivatives of uridine (Vb) and N4-benzoylcytidine (VIb) were used as synthones in machine assisted synthesis of microhelixAla (5'-GGGGCUAUAGCUCUAGCU*CCACCA-3')((X).The compound X was aminoacylated by means of alanyl-t-RNA synthetase (E.coli).