126922-84-7Relevant academic research and scientific papers
Discovery of Cephalosporin-3′-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects against Pseudomonas aeruginosa Clinical Cystic Fibrosis Isolates and Efficacy in a Murine Respiratory Infection Model
Rineh, Ardeshir,Rineh, Ardeshir,Soren, Odel,Soren, Odel,Soren, Odel,McEwan, Timothy,McEwan, Timothy,Ravikumar, Vikashini,Poh, Wee Han,Azamifar, Fereshteh,Azamifar, Fereshteh,Naimi-Jamal, M. Reza,Cheung, Chen-Yi,Elliott, Alysha G.,Zuegg, Johannes,Blaskovich, Mark A. T.,Cooper, Matthew A.,Dolange, Victoria,Christodoulides, Myron,Cook, Gregory M.,Rice, Scott A.,Rice, Scott A.,Rice, Scott A.,Faust, Saul N.,Faust, Saul N.,Faust, Saul N.,Webb, Jeremy S.,Webb, Jeremy S.,Webb, Jeremy S.,Kelso, Michael J.,Kelso, Michael J.
, p. 1460 - 1479 (2020/07/14)
The formation of biofilms provides a formidable defense for many bacteria against antibiotics and host immune responses. As a consequence, biofilms are thought to be the root cause of most chronic infections, including those occurring on medical indwellin
Structure-activity relationships within a series of C(7)-substitutedoxyiminocephalosporins containing the C(3)-methylaminopyridiniumthiomethyl substituent synthesis and biological properties of BRL 57342 and some close analogues
Adams,Brain,Branch,Guest,Harrington,Mizen,Neale,Pearson,Simpson,Smulders,Zomaya
, p. 417 - 424 (2007/10/02)
(6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-[(Z)-[(S)-carboxy(3,4 -dihydroxyphenyl)methyl]oxy-imino]acetamido]-3-(1-methylaminopyridinium-4 -thiomethyl)ceph-3-em-4-carboxylate sodium salt (BRL 57342, If) combines excellent in vitro antibacterial potency against Gram-positive and Gram-negative bacteria, including P. aeruginosa and Acinetobacter spp., with excellent stability to extended spectrum β-lactamases. This potency is reflected in in vivo efficacy studies.
